Real-time, up-to-the-minute access to information provides new opportunities for scientists to monitor cellular events in ever more meaningful ways. Real-time cytotoxicity and cell viability assay reagents now allow constant monitoring of cell health status without the need to lyse or remove aliquots from plates for measurement. With a real-time approach, data can be collected from […]
The HiBiT Technology offers a solution for studying proteins eliminating labor-intensive processes like Western blots and the batch variability of primary antibodies. This innovation facilitates accurate detection and quantification of low-abundance proteins in various applications, enhancing research efficiency.
Recent Legionella outbreaks in New York, Switzerland, and Austria highlighted the importance of rapid testing methods. New York’s slow culture-based testing delayed responses, while Basel’s use of qPCR allowed quicker identification of contamination sources. Adopting qPCR, especially viability qPCR, can enhance safety by enabling faster detection and response to Legionella risks in water systems.
Every neuron relies on a protein called tau to keep its internal skeleton, the microtubule network, working properly. In a group of brain diseases known as “tauopathies,” tau stops doing its job. It misfolds, clumps together, and eventually contributes to the neuron loss that causes memory changes and shifts in behavior. Scientists studying these diseases […]
FDA Regulation changes: The Problem is still Validation In March 2026, the FDA published draft guidance that fundamentally changed how NAMs (New Approach Methodologies) are evaluated in drug development. If you’re designing NAMs, whether that be spheroids, organoids, or organs-on-a-chip, your model now must meet specific validation criteria set by regulators. This draft document, titled […]
In late May 2026, a clinical trial result landed in the New England Journal of Medicine and immediately rewrote what oncologists believed was possible for patients with metastatic pancreatic cancer. Before the paper was published, people in the field were already calling it “transformative.” The data, when it came, agreed. In a disease where most […]
The study investigates how early metabolic changes during T-cell activation affect their expansion and function in adoptive therapies. Researchers identified four metabolic states influenced by culture conditions, revealing that high glycolytic activity corresponds to rapid T-cell proliferation, while oxidative metabolism supports memory-like characteristics. Understanding these dynamics could optimize T-cell manufacturing strategies.
In biologics, cell therapy, and targeted protein degradation, the science is moving fast—and so are the tools. From GPCR-targeted therapies to real-time CAR-T manufacturing tools, new techniques are reshaping how scientists approach drug development, live-cell imaging, and protein degradation. The “Bringing Light to Science” Discover Glo 2025 speaker series brought together researchers from across academia […]
Compared to methods for characterizing compound binding affinity, techniques for assessing kinetic parameters of compound binding can be more laborious (1). Nevertheless, several methodologies have been developed to measure compound residence time, including methods that allow for higher throughput.
Understanding the expression, function and dynamics of proteins in their native environment is a fundamental goal that’s common to diverse aspects of molecular and cell biology. To study a protein, it must first be labeled—either directly or indirectly—with a “tag” that allows specific and sensitive detection. Using a labeled antibody to the protein of interest […]
