What Counts as Evidence

This is the third post of three in a series leading up to the 16th annual International Forum on Consciousness, taking place in Madison this May. Hosted by the BTC Institute, Promega and Usona Institute, the forum gathers scientists, philosophers, and practitioners from dozens of different fields to investigate the nature of the mind. This yearโ€™s theme, โ€œUnspoken Intelligence,โ€ explores forms of perception and knowing that fall outside conventional cognition.

In 1845, mathematician Urbain Le Verrier calculated where an unseen planet had to be based on irregularities in Uranus’s orbit, wrote a letter to an observatory telling them where to point their telescope, and Neptune was there. He found a planet without ever looking up.

This is what third-person inquiry looks like at its best: observe from the outside, measure what anyone with the right instruments can measure, build a model precise enough to predict what no one has seen yet. Then look. The history of science is full of such moments, equations pointing to phenomena that hadn’t been detected, particles that hadn’t been observed, forces that hadn’t been measured. The method works because it is ruthlessly disciplined about what counts as evidence. The observer is removed, the conditions controlled, and the measurement trusted.

That discipline is not a limitation. It is the engine of over four centuries of extraordinary results. It gave us germ theory, the structure of DNA, and the sequenced human genome. Every time something seemed to resist physical explanation, the method eventually found the mechanism and the method held. The winning streak was long enough that the assumption underneath it stopped looking like an assumption. Outside-in, third-person, measurable evidence stopped looking like one way of knowing. It started looking like the definition of knowing itself.

The assumption felt safe because it had earned its confidence. Digestion, heredity, mental illness, each had seemed to resist physical explanation until it didn’t. The pattern was consistent enough that the method felt inevitable rather than chosen.

Then science turned toward consciousness, and the winning streak entered dangerous territory.


Here is the problem, what philosopher David Chalmers named the “hard problem” of consciousness in 1995.

To understand what Chalmers meant, it helps to start with his own illustration. When you see red, something measurable happens. Light hits the retina. Signals travel along the optic nerve. Specific regions of the visual cortex activate in patterns that neuroscientists can map with increasing precision. All of that is, in principle, fully describable by the third-person, outside-in approach. Given enough time and instruments, you can trace the whole sequence.

What you cannot describe from the outside is what red looks like. The redness of red, that specific quality of experience that exists only in the moment of seeing it, is not in the neural map. No better scanner will find it there, because the felt quality of the experience isn’t a physical thing hiding in the data. It exists only from the inside. The outside measurement, however precise, cannot reach it.

Chalmers used “hard” deliberately, in contrast to what he called the “easy problems” of consciousness: how the brain integrates information, focuses attention, produces behavior. Those are genuinely difficult, but the outside-in approach knows how to go after them. The hard problem is different in kind. It’s the question that remains even after you’ve solved all of the “easy” ones: why does any of it feel like anything at all?

Think of it this way: everything the brain does could, in principle, happen without any felt experience attached. Processing, responding, behaving, all of it could run like a machine in the dark, with no one home. The question Chalmers is asking is why it doesn’t. Philosophers ask it this way: why is there something it’s like to be you, right now, reading this?

No amount of outside-in evidence, however precise, touches that question, not because the science is insufficient but because the method was specifically designed to exclude first-person data. That exclusion was the whole point. It’s what made the outside-in approach so powerful everywhere else.

With consciousness, the method’s central design decision runs into a question it wasn’t built to answer: how do you study first-person experience when your method was built to exclude first-person data?

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The Filter You Didn’t Choose

This is the second post in a series leading up to the 16th annual International Forum on Consciousness, taking place in Madison this May, hosted by the BTC Institute, Promega and Usona Institute. The Forum gathers scientists, philosophers, and practitioners from dozens of different fields to investigate the nature of the mind. This yearโ€™s theme, โ€œUnspoken Intelligence,โ€ explores forms of perception and knowing that fall outside conventional cognition.

When she thought about a dog, she saw a dog, more specifically, every dog she had ever encountered, cycling through her mind like a card catalog with pictures attached. She assumed everyone did this. When she discovered they didn’t, that most people access something more like an abstract concept hovering somewhere between language and image, she was genuinely surprised. Temple Grandin had always known her mind didn’t work the way people expected. What she didn’t know, until she was an adult, was the specific shape of the difference.

Most of us know this story, or one like it. We understand that some minds filter experience differently, but the science on this doesn’t stop where the conversation usually does.


For most of its history, the field that mapped minds like Grandin’s looked at those that didn’t fit the available systems and concluded the minds were broken. (It didn’t ask whether the systems were.) More recently, the conversation has been reframing those minds not as deficient but as different.

For many people, that reframing has been transformative, changing how educators teach, how clinicians diagnose, and how workplaces are designed. We are now more familiar with alternative cognitive profiles such as autistic pattern recognition (like that experienced by Grandin), ADHD-associated divergent thinking, and the hyper-focused depth of what researchers call monotropic attention. These are not broken versions of normal cognition. They are different architectures, each with genuine capabilities that other minds aren’t built to produce.

The terms most commonly used to describe these differences, neurotypical and neurdivergent, are useful shorthand but they describe a binary the underlying biology doesn’t support. Cognitive traits distribute across a population the way most biological traits do. “Neurotypical” minds are simply closer to the statistical center. What we call “neurodivergent” can be better understood as the part of that population that differs visibly enough from the statistical center to make the variation impossible to ignore.


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The Body Already Knows

This is the first post in a series leading up to the 16th annual International Forum on Consciousness, taking place in Madison this May, hosted by the BTC Institute, Promega and Usona Institute. The Forum gathers scientists, philosophers, and practitioners from dozens of different fields to investigate the nature of the mind. This year’s theme, โ€œUnspoken Intelligence,โ€ explores forms of perception and knowing that fall outside conventional cognition.

There’s a quote that travels well in some intellectual circles:

You don’t have a soul. You are a soul. You have a body.

There’s something genuinely relieving about that idea. It locates the real you somewhere above the fray, untouched by the body’s demands and indignities, the consciousness that thinks and persists while the body handles the inconvenient work of being hungry and tired and sick. The thinking part is what counts.

Plato thought something similar. So did Augustine. As did Descartes. Kant, too. The idea that the thinking self is separate from and superior to the body is Western civilization’s default setting.

It sounds like wisdom. It is also, I’ve come to think, exactly the wrong way to understand what we are.

Here’s a different text, one most millennials can recite from memory. In the opening verse of “Lose Yourself,” Eminem rattles off a visceral catalog of physical symptoms: sweaty palms, weak knees, heavy arms, vomiting. The body staging a complete revolt while the mind tries to execute a plan, until the moment on stage when the mouth opens and nothing comes out. The mind wanted to perform, but the body said no.

Nobody who has memorized those lyrics thinks of them as a description of embodied cognition. They file it under music, or nostalgia, or just a song they played too loud in a car they didn’t own. But the nervous system doesn’t care what you call it, because the body doesn’t catalogue in words.

This is the thing the soul-body quote gets wrong: the body isn’t a vehicle the self rides around in. It’s already thinking, already keeping score, already running a process the mind is only partially aware of. The question is what to do about that.

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CRISPR/Cas9 Knock-In Tagging: Simplifying the Study of Endogenous Biology

Understanding the expression, function and dynamics of proteins in their native environment is a fundamental goal thatโ€™s common to diverse aspects of molecular and cell biology. To study a protein, it must first be labeledโ€”either directly or indirectlyโ€”with a โ€œtagโ€ that allows specific and sensitive detection.

Using a labeled antibody to the protein of interest is a common method to study native proteins. However, antibody-based assays, such as ELISAs and Western blots, are not suitable for use in live cells. These techniques are also limited by throughput and sensitivity. Further, suitable antibodies may not be available for the target protein of interest.

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Bringing Science to Life: How Art and Sustainability Shape Our New Trade Show Booth Design

Step inside a Promega booth and leave the ordinary behind. Here, science sparks creativity, sustainability is woven into every detail, and discovery isn’t just something you seeโ€”it’s something you feel.

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The Central Dogma of Promega: The Story and Science Behind Our Kit Packaging Design

An amazing transformation is taking place, unseen and unnoticed, within the microscopic bits that make you, you.

A tightly coiled lattice unspools to reveal a sinuous DNA stand. Along its length, tendrils of RNA sprout, growing bit by genetic bit. Eventually, the signal to stop and break away arrives, yielding a new strand of RNA that faithfully transcribes the DNA strand’s genetic code. Proteins trim and splice this new growth, pruning it so it takes its final form, messenger RNA. More proteins then ferry this mRNA strand through a pore in the nuclear envelope into the open space of the cellโ€™s cytoplasm. Ribosomes and codon-carrying tRNA alight onto the released mRNA strand, reading the instructions it has carried from the DNA in the nuclear nursery. From this trio new forms emerge, bulbous proteins shaped by their destined purpose.

And so it goes, every second of every day, in the tens of trillions of cells in your bodyโ€ฆ

โ€ฆAnd on the tens of thousands of kit packages we deliver to customers across the globe every year.

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Celebrating 10 Years of Innovation: Introducing the CSCB-Promega Innovation Fundย 

For the past decade, Promega has supported cutting-edge research through the CSCB-Promega Innovation Award. Now, as we mark 10 years of collaboration with the Chinese Society for Cell Biology (CSCB), the Award is being converted into the CSCB-Promega Innovation Fund.  

The CSCB, founded in 1980, is one of the leading scientific organizations in China. Dedicated to fostering educational opportunities and innovation, the CSCB organizes conferences, publishes journals, promotes research collaborations, offers training for students and young scientists, and educates the general public on cell biology and biomedicine. 

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Blending Art and Science in a Costa Rica Physics Lab

Sophia Speece engaged her passions for art and science during her internship in Costa Rica.
UW-Madison student Sophia Speece (left) spent the summer in Costa Rica for the “Artist in the Science Lab” internship hosted by alum Dr. Mariela Porras Chaverri (right)

My name is Sophia Speece. I am a junior at the University of Wisconsin-Madison studying Biomedical Engineering and Music Performance. As you can imagine, there is not a lot of overlap between these two passions of mine.

This past summer I was given the unique opportunity to combine these two areas. I applied and was accepted for the โ€œArtist in the Science Labโ€ internship abroad in Costa Rica!

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Insights from our Second Annual Targeted Protein Degradation Symposium

In the opening remarks of our second annual Targeted Protein Degradation Symposium, Tom Livelli, VP of Life Sciences Products & Services at Promega, posed a question to the attendees: โ€œWhat do you want to be able to do today that you canโ€™t?โ€ This aspirational question set the tone for an event where building connections to advance the study and application of proximity-induced degradation took center stage.

More than 90 attendees from academia and industry gathered September 20โ€“21 for the two-day symposium, which was hosted in our inspirational Kornberg Centerโ€”the R&D heart of Promega. Through engaging talks, a poster session, โ€œLearn nโ€™ Burnโ€ challenges and social gatherings, participants had the opportunity to reinforce existing collaborations and to connect with others who are making an impact in the field of targeted protein degradation.

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Promega Fall Art Showcase Honors Truman Lowe, Ho-Chunk Artist and Mentor

Truman Lowe, Ho-Chunk artist and mentor, pictured with Headdress (1989)

Outside the BioPharmaceutical Technology Center, the wind snakes through the tall prairie grasses, drying slowly in the crisp September air. The walking paths through the woods are turning orange with fallen leaves, and the resident sandhill cranes, a fixture of summer at Promega Madison, will soon be heading to their winter home in southern Florida.

Inside the BTC, the Promega Fall Art Showcase is honoring the life of Truman Lowe, an acclaimed Ho-Chunk artist whose sculptural works evoke a powerful connection with nature. For decades, Lowe was a professor in the Department of Art at the University of Wisconsin-Madison where he was an exceptional mentor to young artists. He was known for encouraging artists to fearlessly delve into their artistic voice and equipping them with the necessary tools to navigate the art world. The Fall Art Showcase honors his legacy by exhibiting his art alongside pieces by several former students.

Truman Lowe: Visionary Artist, Mentor and Teacher

Truman Lowe was born on the Ho-Chunk Nation of Wisconsin reservation in 1944. He recounted a childhood of drawing with rocks on the Black River and creating crafts like baskets and beadwork with his parents. Though he loved art from an early age, Lowe says that he never thought of art as a profession until he was studying for his undergraduate art degree at the University of Wisconsin-LaCrosse. There, he became fascinated with Michelangelo, who inspired him to realize that art could be โ€œa profession as well as a passion.โ€1

Visitors to the Promega Fall Art Show can see sculptures by Truman Lowe alongside works by several of his students.

After earning a graduate degree and moving through several teaching positions at the high school and university level, Lowe accepted a position as Native American studies coordinator and assistant professor of art at UW-Madison in 1975. This began a 45-year tenure in the department of art, where he fostered a deep understanding and appreciation for Native American art and culture among his students. He also served as a curator of contemporary art at the National Museum of the American Indian.

Lowe is known for large, site-specific installations that use natural materials including wood, stone and metal. His works push creative boundaries and exhibit a unique blend of versatility, precision and emotional depth. Loweโ€™s sculptures have been exhibited around the world, from museums including the Metropolitan Museum of Art to embassies in Bolivia and Cameroon. A sculpture titled Effigy: Bird Form was displayed on the White House grounds during the Clinton administration and was recently reinstalled atop Observatory Hill at UW-Madison, close to the former site of Native American effigy mounds. 

Lowe, who died in 2019, was a beloved mentor to many students over his long tenure at UW-Madison. A university-published obituary quotes John Hitchcock, professor and Associate Dean at UW-Madison, saying, โ€œTruman encouraged us to stay strong as artists and to our vision as makers.โ€ The widespread love of Lowe will be on display at the Promega Fall Art Showcase, where six of his former students will be exhibiting alongside Loweโ€™s own works.

Promega Fall Art Showcase

The Fall Art Showcase opened on September 19 with a symposium featuring guest speakers Patricia marroquin Norby and Jo Ortel. Norby is the Associate Curator of Native American Art at the metropolitan Museum of Art, and the first person of Indigenous descent hired for a full-time curatorial position in the museumโ€™s 150-year history. Jo Ortel is an author, art historian and Professor Emerita of Art History of Beloit College. Ortel is also the author of a notable biography of Truman Lowe titled โ€œWoodland Reflections: The Art of Truman Lowe.โ€

The Promega Culinary Team collaborated with Chef Elena Terry of the culinary organization Wild Bearies to offer traditional Ho-Chunk food at the reception. Chef Terry provided recipes and connected the team with indigenous purveyors to source ingredients. Promega also collaborated with Little Eagle Arts Foundation to include pieces of Ho-Chunk culture into the event.

The Fall Art Showcase runs through December 29 and is open to the public Monday through Friday 8:00 am โ€“ 4:00 pm at the Promega BioPharmaceutical Technology Center. For more information, visit https://www.promega-artshow.com/

1As quoted in Woodland Reflections: The Art of Truman Lowe by Jo Ortel


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