As announced at SLAS in Washington, D.C. recently, we are excited to have NanoBRET™ Target Engagement (TE) Intracellular Kinase Assays awarded the SelectScience Reviewers’ Choice for Drug Discovery and Development Product of the Year 2019!
The NanoBRET™ Target Engagement (TE) Kinase Assay, first available in the fall of 2017, has been getting great reviews on the SelectScience site for more than a year now.
We are grateful to have been selected for this award and for reviewers’ votes and comments! Some of the comments include:
Here are some details on what this assay can do as a tool in your drug discovery and development research.
What is the NanoBRET™ TE Kinase Assay ?
NanoBRET™ TE Intracellular Kinase Assays are the first biophysical method to enable the quantitative determination of compound potency and binding affinity for specific kinase targets inside live cells. The assays provide a direct measure of compound binding or occupancy to a target kinase under physiological conditions.
Ready-to-use target-specific cellular assays included in the NanoBRET™ TE Kinase family have been developed for >200 full-length kinases, including integral membrane receptor tyrosine kinases, as well as kinases that rely on regulatory proteins like the cyclin-dependent kinases.
All assays use a simple protocol that is conducted in multiwell plates and is scalable from 96-well to 384-well formats. The data quality from these NanoBRET™ TE Kinase Assays is excellent, with low error rates and high reproducibility.
Cellular potency of multiple kinase inhibitors types (I, II and allosteric compounds) have been measured using NanoBRET™ TE Kinase assays. Additionally, the NanoBRET™ TE Kinase assays are versatile and can be configured for kinetic or residence time analysis that enables the investigation of the duration of binding between a compound and a specific kinase in live cells.
Learn more about the NanoBRET™ TE Intracellular Kinase Assays at this product page, where you’ll find data, the protocol and a paper on how these assays have been applied to kinase profiling in live cells.
We hope you’ll find NanoBRET™ TE Kinase Assays a useful, exciting tool in your drug discovery and development workflow.