Cowpea (Vigna unguiculata), a humble tan and black legume, is one of the most important food crops in the world. Grown across sub-Saharan Africa, Asia, and parts of the Americas, Cowpea provides protein-rich nutrition for hundreds of millions of people, making it a cornerstone of smallholder agriculture. But cowpea production faces a persistent threat: the […]
The Promega Canine PD-1/PD-L1 Blockade bioassay is enabling a new generation of immune checkpoint antibody research and accelerating therapeutic development for canine cancer while, at the same time, yielding new knowledge of pathways relevant to human oncology.
Introduction Lipid nanoparticles (LNPs) have transformed mRNA delivery. From COVID-19 vaccines to the first approved RNAi therapeutic, ONPATTRO (Patisiran), LNPs have proven their ability to ferry nucleic acid cargo into cells with speed and efficiency (Huang, 2019). Despite this transformation, most clinically deployed LNP formulations share a significant constraint: following intravenous administration, roughly 90% of […]
Many consider enzymes the workhorses of biochemistry (move over, mitochondria)—catalyzing reactions, breaking down substrates, keeping the machinery of life humming along. But a growing number of researchers are re-envisioning what enzymes can do. Instead of facilitating chemistry, what if enzymes could steer and even guide tiny robots to a tumor? That’s exactly what’s happening in the rapidly expanding field of […]
What if a vaccine didn’t come in a vial or a syringe, but in a pint glass? It’s the kind of question that sounds hypothetical–something meant to provoke discussion rather than describe a real experiment. And yet, it’s one that a virologist claims to have taken seriously enough to test in his own kitchen. Since […]
This article by Kai Hillman, PhD, discusses the innovative role of Promega Fc Effector Assays in advancing monoclonal antibody (mAb) development. It emphasizes the importance of Fc region engagement for immune response and highlights how these assays enhance precision and reproducibility in early-stage screening, optimization, and regulatory processes for immunotherapies.
For research use only Introduction: Diagnostic Innovation for Zoonotic Threats When a veterinarian detects influenza A in pigs, they’re not just protecting a herd; they’re helping safeguard public health through broad ongoing surveillance. To support rapid, biosafe detection of Influenza A viruses (H5N1, H3N2, H1N1) in animal populations, Promega and Longhorn Vaccines and Diagnostics have […]
Targeted protein degradation (TPD) is an emerging drug discovery strategy that offers an entirely different approach to tackle disease-relevant proteins, including classic “undruggable” targets. Instead of inhibiting protein function, small molecules like PROTACs and molecular glues co-opt the cell’s own ubiquitin-proteasome system to eliminate specific proteins altogether. But as this targeted approach gains traction, it also […]
Metastasis of melanoma poses significant threats, especially to the brain, with low survival rates once advanced. A new microphysiological system developed by Reed-McBain et al. simulates tumor-stroma interactions in the brain, allowing for detailed metabolic assessments and visualization of nutrient diffusion. This innovative model offers potential improvements in therapeutic screening for melanoma brain metastases.
In the webinar by Dr. Kristin Riching, the importance of real-time degradation kinetics in targeted protein degradation is highlighted. Kinetic data surpass traditional static assays by revealing crucial insights into degrader performance, aiding in drug design and optimization. Tools like the HiBiT tagging system simplify analysis, enhancing workflows in early discovery settings.
