For research use only Introduction: Diagnostic Innovation for Zoonotic Threats When a veterinarian detects influenza A in pigs, they’re not just protecting a herd; they’re helping safeguard public health through broad ongoing surveillance. To support rapid, biosafe detection of Influenza A viruses (H5N1, H3N2, H1N1) in animal populations, Promega and Longhorn Vaccines and Diagnostics have […]
Targeted protein degradation (TPD) is an emerging drug discovery strategy that offers an entirely different approach to tackle disease-relevant proteins, including classic “undruggable” targets. Instead of inhibiting protein function, small molecules like PROTACs and molecular glues co-opt the cell’s own ubiquitin-proteasome system to eliminate specific proteins altogether. But as this targeted approach gains traction, it also […]
Metastasis of melanoma poses significant threats, especially to the brain, with low survival rates once advanced. A new microphysiological system developed by Reed-McBain et al. simulates tumor-stroma interactions in the brain, allowing for detailed metabolic assessments and visualization of nutrient diffusion. This innovative model offers potential improvements in therapeutic screening for melanoma brain metastases.
In the webinar by Dr. Kristin Riching, the importance of real-time degradation kinetics in targeted protein degradation is highlighted. Kinetic data surpass traditional static assays by revealing crucial insights into degrader performance, aiding in drug design and optimization. Tools like the HiBiT tagging system simplify analysis, enhancing workflows in early discovery settings.
The Wnt/β-catenin pathway, long studied in the context of developmental biology, has become increasingly recognized for its role in a wide range of human diseases. Its dysregulation has been implicated in cancer, fibrosis, immune modulation, and neurodegenerative conditions—making it a clinically actionable target across diverse therapeutic areas1. In this blog, we cover the fundamentals of […]
Labeled antibodies are indispensable tools in research and clinical diagnostics, used in everything from cell imaging and ELISAs to immunotherapies and ADC development. But if you’ve ever tried labeling antibodies the traditional way—purify, buffer exchange, conjugate, purify again—you know it can be tedious and time-consuming. That’s where on-bead conjugation steps in with a solution.
Tuberculosis (TB) remains one of the deadliest infectious diseases globally, with millions of new cases and over a million deaths each year. The rise of drug-resistant strains has only complicated treatment and control efforts, turning TB into a moving target for clinicians and public health officials alike. Understanding how TB spreads, evolves and becomes resistant […]
Antibody-drug conjugates (ADCs) are an increasingly powerful class of cancer therapeutics that combine the targeted precision of monoclonal antibodies with the cytotoxic potency of small-molecule drugs. By directing chemotherapy agents specifically to tumor cells, ADCs aim to maximize antitumor activity while minimizing damage to healthy tissues. One key challenge in ADC design is selecting the […]
From enzyme activity to gene expression, light-based assays have become foundational tools in life science research. Among these, fluorescence and bioluminescence are two of the most widely-used approaches for detecting and quantifying biological events. Both rely on the emission of light, but the mechanisms generating that light—and the practical implications for experimental design—are quite different. […]
This winter, norovirus outbreaks surged across the U.S., with cases nearly doubling from last year, according to the CDC. Schools, cruise ships, nursing homes and healthcare facilities saw widespread illness, underscoring the urgent need for a norovirus vaccine. Each year, norovirus causes 685 million infections worldwide and is the leading cause of foodborne illness in […]
