Author: Kelly Grooms

New Study Suggests Cancer Research Has an Age Problem

Posted on by Kelly Grooms
White lab mouse among test tubes overlaid with a blue DNA helix.

Most cancer research relies on young, healthy mice. Most cancer patients are not young. Could this disconnect between model organism and patient, which ignores the impact of the physiological realities of aging, explain why some therapies perform well in the lab but not in clinical trials? Focusing on lung cancer, a study published in Nature investigated what happens when these two realities, young and old, finally meet in the lab (1). The answers could reshape how we think about cancer research and the impact of aging on metastasis and disease progression.

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Polar Bears, Shrinking Sea Ice and a Scientific Surprise

Posted on by Kelly Grooms
A polar bear sits on a snow-covered ice floe in the Arctic Ocean, gazing toward the horizon as sunlight filters through clouds over icy water.

When you think about climate change in the Arctic, you might imagine melting sea ice or maybe hungry polar bears. After all, polar bears depend on sea ice to hunt seals, and seals are their main source of energy. The negative effects of decreasing sea ice on polar bear body condition index (BCI), survival and reproduction have been documented in polar bear populations from regions such as the Western Hudson Bay and the Southern Beaufort Sea. So, when researchers started studying the polar bears in Svalbard, Norway (Barents Sea region), which is losing sea ice at a faster rate than any other region, they expected the BCI of those bears would also be declining. Except it isn’t.

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From Forever Chemicals to Ancient Proteins: Five Science Stories from 2025

Posted on by Kelly Grooms

As science advances, its most meaningful moments often come not in a single breakthrough, but in the accumulation of insights that reshape how we understand our world. As we close the door on 2025 it is worth pausing to reflect on some of the discoveries of the past year that stood out—not just for their technical achievement, but for what they reveal about our planet, our past and ourselves. From dismantling so-called “forever chemicals” to reading molecular histories written millions of years ago, these five stories offer a snapshot of the breadth, creativity and impact of modern scientific inquiry.

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World Wildlife Conservation Day: Reflecting on the Role of Science in Protecting Threatened or Endangered Species and Ecosystems  

Posted on by Kelly Grooms
A sign reading “Wildlife Conservation Area — Please keep to marked footpaths” stands in the foreground of a grassy field, with rows of young crops and a line of trees under a partly cloudy sky.

December 4 marks World Wildlife Conservation Day, a day set aside to highlight global efforts to protect endangered species and preserve the biodiversity and ecosystems that sustain our planet. It is an opportunity to call attention to the serious threats posed by wildlife crimes, such as poaching and illegal trafficking, and a time to stand together against ongoing dangers to wildlife and their habitat.  

Every organism, from myxozoans to blue whales, has a place in the delicate balance of ecosystems. When these systems become unstable, the impact can be far reaching—affecting anything from crop loss and soil fertility to water and air quality. This World Wildlife Conservation Day we want to reflect on the role science can play in understanding and protecting the wildlife and ecosystems that support us all.  

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Unlocking the Power of Live-Cell Kinetics in Degrader Development

Posted on by Kelly Grooms

In targeted protein degradation (TPD), timing is everything. Understanding not just whether a degrader works—but how fast, how thoroughly and how sustainably—can dramatically influence early discovery decisions. Dr. Kristin Riching (Promega) dove into the real-time world of degradation kinetics in the webinar: Degradation in Motion: How Live-Cell Kinetics Drive Degrader Optimization, sharing how dynamic data provides a clearer view of degrader performance than traditional endpoint assays.

Whether you’re exploring your first PROTAC or optimizing a molecular glue series, the expertise offered in Dr. Riching’s presentation gives you actionable insights that will help you connect kinetic data to better therapeutic design.

3D visualization of a protein structure within a live-cell environment, highlighting the interaction site relevant to targeted protein degradation, set against a dark cellular background to emphasize kinetic dynamics.
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Avoid the Summertime Blue-Greens— Know about Cyanobacteria Before You Hit the Water

Posted on by Kelly Grooms
Warning sign reading "ALGAE BLOOM – NO SWIMMING" posted in a lake with visible green algae floating on the water's surface, surrounded by lily pads and aquatic plants under a clear blue sky.

The weather is warming up (at least in the Northern Hemisphere). There is nothing more refreshing on a hot summer day than a dip in cool lake waters, so people everywhere are digging out their swimsuits and hitting the beach. Unfortunately, the same warm temperatures that drive us to the beach can also cause a potentially deadly overgrowth of blue-green algae —also called harmful algal blooms (HABs)—in the water of our favorite pond or lake.

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Growing Our Understanding of Triple-Negative Breast Cancer in Sub-Saharan Africa: Why Comprehensive Population Data Matters

Posted on by Kelly Grooms
A digitally rendered illustration of a cancer cell superimposed over the African continent. The cancer cell, with a textured, reddish-orange surface and extending tendrils, appears to spread across the dark red map of Africa, symbolizing the impact or presence of cancer on the continent.

In the genomics era, the promise of precision medicine and tailored diagnostics is only as good as the datasets, which makes it imperative that those sets reflect the diversity of the human population. Populations from the African continent, the most genomically diverse region in the world, are underrepresented in current genomic data sets.  Nowhere is closing this data gap more urgent than with triple-negative breast cancer (TNBC), which has a disproportionately high incidence in women of African descent and limited therapeutic options.

Highlighting why comprehensive population data is so important are the results of a recent study profiling of 30 TNBC tumor samples from Angola and Cape Verde (1).  Whole-exome sequencing (WES), enriched with untranslated regions (UTRs), showed that 86% of somatic variants in these samples had never been reported before. WES can be especially valuable when working with limited or degraded samples, such as the FFPE samples used in this study, because it allows you to gain valuable insights from samples that are impractical for whole-genome sequencing (WGS). This study’s results emphasize the value in expanding omics cancer research so that it includes all populations and areas of the genome.

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Measles and Immunosuppression—When Getting Well Means You Can Still Get Sick

Posted on by Kelly Grooms
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In 2000 measles was officially declared eliminated in the United States (1), meaning there had been no disease transmission for over 12 months. Unfortunately, recent years have shown us it was not gone for good. So far in 2025 there have been 6 outbreaks and 607 cases. Five hundred and sixty-seven of these cases (93%) are associated with an outbreak; seventy-four (12%) cases have resulted in hospitalization, and there has been one confirmed death, with another death under investigation (as of April 3, 2025; 2).  For comparison, there were two hundred and eighty-five total cases in 2024; one hundred and ninety-eight (69%) were associated with outbreaks; one hundred and fourteen (40%) cases resulted in hospitalization. There were no deaths (2).  

Help in Limiting a Dangerous Childhood Disease

Before the development of a vaccine in the 1960s, measles was practically a childhood rite of passage. This common childhood disease is not without teeth however. One out of every 20 children with measles develops pneumonia, 1 out of every 1,000 develops encephalitis (swelling of the brain), and 1 to 3 of every 1,000 dies from respiratory and neurological complications (3). In the years before a vaccine was available, it is estimated that there were between 3.5 and 5 million measles cases per year. (4). The first measles vaccine was licensed in the U.S. by John Enders in 1963, and not surprisingly, after the measles vaccine became widely used, the number of cases of measles plummeted. By 1970, there were under 1,000 cases (2).

Decreased Childhood Mortality from Other Infectious Diseases—An Unexpected Benefit

Surprisingly, with the disappearance of this childhood disease the number of childhood deaths from all infectious diseases dropped dramatically. As vaccination programs were instituted in England and parts of Europe, the same phenomenon was observed. Reduction or elimination of measles-related illness and death alone can’t explain the size of the decrease in childhood mortality. Although measles infection is associated with suppression of the immune system that will make the host vulnerable to other infections, these side effects were assumed to be short lived. In reality, the drop in mortality from infectious diseases following vaccination for measles lasted for years, not months (5).

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IC50, EC50 and Kd: What is the Difference and Why Do They matter?

Posted on by Kelly Grooms
A modern computer monitor displays a data analytics graph with an upward-trending line in orange and red. The screen has a dark theme with a grid overlay and numerical values. The monitor is set on a desk with a keyboard and mouse, illuminated by warm ambient lighting in the background, creating a professional, high-tech atmosphere.

Three of the most common metrics in drug discover are Kd, IC50 and EC50. At first glance it can seem that they measure the same thing, but they don’t. Kd measures how tightly a molecule or compound binds to its target. IC50 measures inhibition of a function and conversely, EC50 measures activation or induction of a response. Confusing these values can lead to misinterpretation of assay results and costly rework. Let’s take a closer look at each one.

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Understanding Stress Resilience in Tomatoes: Insights Into the Role of PP2C Genes

Posted on by Kelly Grooms
An illustration of a tomato plant divided between normal and drought conditions. This study looks at the role of PP2C in stress response.

As climate change accelerates, understanding how crops survive environmental stress isn’t just an academic question—it’s a critical challenge for global food security. Tomatoes (Solanum lycopersicum), a staple crop worldwide, face increasing threats from drought, salinity, and extreme temperatures. But how do these plants adapt at the molecular level?

A recent study published in Scientific Reports ​investigated the evolutionary history, genomic diversity, and functional roles of protein phosphatase 2C (PP2C) genes in tomatoes (1). Instead of merely cataloging these genes, the researchers analyzed how PP2C gene expression changes under environmental stress. This information could help inform us about crop improvement strategies.

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