SLIM Chances: Upside-down, but not Out on the Lunar Surface

The lunar surface

The moon has perpetually been a beacon of curiosity to humankind, always in the sky urging us to look up and beyond. In the mid-20th century, this fascination sparked a historic rivalry between the United States and the Soviet Union, known as the Space Race. This era was marked by extraordinary milestones: satellites orbiting Earth, humans venturing into space and the landmark event of a man setting foot on the moon – a moment etched in history with the phrase, “One small step for (a) man, one giant leap for mankind.” It was an era where the impossible became possible – though some still question if it was a monumental human achievement or an elaborately crafted façade.

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Blending Art and Science in a Costa Rica Physics Lab

Sophia Speece engaged her passions for art and science during her internship in Costa Rica.
UW-Madison student Sophia Speece (left) spent the summer in Costa Rica for the “Artist in the Science Lab” internship hosted by alum Dr. Mariela Porras Chaverri (right)

My name is Sophia Speece. I am a junior at the University of Wisconsin-Madison studying Biomedical Engineering and Music Performance. As you can imagine, there is not a lot of overlap between these two passions of mine.

This past summer I was given the unique opportunity to combine these two areas. I applied and was accepted for the “Artist in the Science Lab” internship abroad in Costa Rica!

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More Than a Scientist: Paraj Mandrekar’s Career & Contributions to Tabletop Roleplaying Games

Paraj Mandrekar began his career at Promega in 1998 in the Genetic Identity Research and Development program. In 2001, he was a consultant at the World Trade Center to help meet the urgent need to identify victims of the 9/11 attacks. Two products, one of them being our DNA IQ™ System, that Paraj and others used for automating forensic DNA purification at the time were featured in the R&D 100 Award in 2002.

As he progressed through the successive ranks in R&D, Paraj took on more responsibility for the research, design, and development of novel chemistry. A significant high point in his career was being promoted to Senior R&D Scientist 1 in 2010. At that point, he was working on both forensic and non-forensic chemistries with paramagnetic particles. Promega’s non-forensic kit (AS1290) was launched with a new chemistry in March 2010, and a few months later, he got a new version of the Maxwell forensic sample kit (AS1240) out the door.

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Promega’s Top Three Most-Viewed Blog Posts of 2023

This year, our bloggers wrote about a range of topics, including semaglutide, a 20,000-year-old pendant, and type 1 diabetes. Each topic is unique and has proven its popularity by our Promega Connections readers! Take a look at our top three most-viewed blog posts of 2023. 

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Designing Science: A Behind-the-Scenes Look at Our Recent Journal Cover Art

A 3D illustration showing RAF inhibitor LXH254 engages BRAF or CRAF protomers (orange), but spares ARAF (red). Unoccupied ARAF is competent to trigger downstream mitogenic signaling, which is demonstrated with lightning bolts. Red cells in the background are fluorescently labeled RAS proteins, expressed in live cells. The Cell Chemical Biology cover type superimposes the image.
Image adapted from original artwork by iSO-FORM LLC.

We made the cover! Of Cell Chemical Biology, that is.

This July, Cell Chemical Biology editors accepted a study from Promega scientists and invited the research team to submit cover art for the issue. The study in question details a BRET-based method to quantify drug-target occupancy within RAF-KRAS complexes in live cells. Promega scientists Matt Robers and Jim Vasta collaborated with one of our talented designers, Michael Stormberg, to craft an image that accurately represents the science in a dynamic and engaging way.

You can check out the paper and cover art in the November 16 issue of Cell Chemical Biology.

I spoke with Michael Stormberg to learn more about the creative process that went into creating this cover art and how he worked with the research team and other collaborators.

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Myths, Misconceptions and Debated Theories in Biology

Research studies and novel discoveries continually reshape our understanding of the natural world, often refining—and sometimes contesting—prevailing scientific theories. While this influx of new information is important for expanding knowledge, it can also give rise to myths and misconceptions stemming from biases, media misrepresentations and overgeneralizations. In this blog, we’ll explore misconceptions that blur the lines between fact and fiction, some scientific myths that just won’t go die and theories that scientists can’t stop debating.

Humans Only Use 10% of Their Brain 

This myth, frequently perpetuated through movies like Lucy with Scarlett Johansson and Limitless with Bradely Cooper, has ambiguous roots. Some attribute this pseudoscience to Albert Einstein, despite no recorded record of such a claim, while others associate it with a misinterpretation of William James and his “Reserve Energy Theory” (8). 

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3.14 Ways to Make Pi Day a Piece of Cake!

Celebrated each year on March 14th (3.14), Pi Day commemorates the irrational, transcendent, and never-ending ratio that’s used to represent a mathematical constant. This infinite number is crucial when describing circles because no matter how big or small, the ratio of a circle’s circumference to its diameter will always equal to pi.

In 2009, pi day, also written π or 3.14, was declared an official national holiday–one that’s worth celebrating! We’ll help you kick things off with 3 fun facts, 1 joke, and 4 activities that are certain to get you in the Pi Day spirit.

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Avoid the Cloning Blues This Season

I was blasting a holiday music playlist while driving recently, and Presley’s Blue Christmas played. I couldn’t get the phrase “Christmas Cloning Blues” out of my mind, and by the time I arrived at my destination, this happened:

Cloning Blues Christmas

(to the tune of Blue Christmas by Elvis Presley)

Blue and white colonies on a selective plate. Careful planning can help you avoid the cloning blues
Blue/White cloning is a standard technique in molecular biology labs.

I’ll have a blue Christmas without you

Colonies so blue, insert without you

Incubating my plates at 37 degrees

Won’t be the same if you’re not in lacZ


And all those blue colonies are forming

When my lab mates’ clonings are performing

They’ll be doing alright,

With their plates all filled with white

But I’ll have a blue, blue, blue cloning

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The Crows Have Ideas

How smart are crows? A crow stares at a mobile phone

It has become increasingly evident to scientists that the intellectual prowess of your average crow has been roundly underestimated. With remarkable skills including superior social acumen, analogical thinking and the ability to craft and use tools, crows seem to prove themselves more and more clever with every investigation into the inner workings of their small, but mighty, brains.

Most recently, new research has revealed that crows may be capable of recursion, a hallmark feature of advanced linguistic ability originally posited by Noam Chomsky in his hierarchy of grammars. Recursion in language is used to grow the complexity of sentence structure to contain, in theory, an infinite number of embedded elements or ideas. Put simply, linguistic recursion refers to the nesting of one grammatical structure, this sentence for example, within another of the same kind. Formerly thought to be a skill exclusive to primates, research like that recently published in Science Advances has challenged this assumption.

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From Outside the Window to Inside the Cell: How Photography has Broadened Our View of the World

Photography. From the time the first image was captured almost 200 years ago, people have been using photography techniques to record, improve and expand their world.  Joseph Nicéphore Niépce is credited with capturing the very first photograph—a view of outside his window—using a technique called heliography. From that blurry, one-of-a-kind print to the stunning images captured today we can capture using our mobile phones, the advances in personal photography have been phenomenal. But progress has not been limited to capturing images of the world we see, scientists have leveraged these advances into new tools to capture images of the world we can’t see.

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