Synthetic biology has been in the news a lot lately—or maybe it only seems like it because I’m spending a lot of my time thinking about our partnership with the iGEM Foundation, which is dedicated to the advancement of synthetic biology. As the 2019 iGEM teams are forming, figuring out what their projects will be and how to fund them, it seemed fitting to share some of these stories.
The 2019 iGEM Competition is on the horizon and team registration opens this month. We’re excited to partner with the iGEM Foundation again this year and offer our support to the young scientists who participate. If you’re starting an iGEM project, there are going to be things you need along the way. We are pleased to share a number of different ways we can help your iGEM team from now until the Giant Jamboree.
Imagine you are a high school student living in a community devastated by gun violence and death. In the U.S., this could be one of many communities, but it happens to be Baltimore which had 301 deaths due to gun violence in 2017 (with a per capita rate well above other large cities). Then imagine you were part of an organization within that community that helped you, along with other students, gain knowledge and skills to come up with a viable solution to the problem using synthetic biology.
This is exactly how the Baltimore Bio-Crew came up with their iGEM project, Coagulance Rx. The Baltimore Bio-Crew decided to tackle this community issue head-on. One team member, Mercedes Ferandes, reflected, “Living in Baltimore City, I have not only witnessed gun violence in front of me, but have had family members and friends die from it. I wanted to try to decrease the amount of deaths by gun violence using iGEM.”
After some research, they discovered that many of the gun deaths were due to blood loss and could have been prevented. The impoverished neighborhoods where this violence occurs lack the resources to provide timely emergency medical treatment. Many of these deaths can be attributed to delayed arrival of emergency response teams—wait times for an ambulance can be over an hour.
Although there were several contributing factors beyond their control, the team wanted to address this problem by focusing on blood clotting and how it could be helpful as a quick temporary treatment for open wounds. This solution could offer a reliable, cost efficient way to save lives by slowing or stopping blood loss until a victim could get medical attention. The team decided to pursue the use of snake venom after coming across some previous iGEM projects that had used it for clotting. Team member Henry Ryles pointed out that the need for snake venom powerful enough to clot blood quickly led them to choose the venom of the Russell’s Viper (Daboia russelii).
Judy Nguyen wasn’t looking for an adventure as the Head of Scientific Research at a fledgling incubator for students. She just finished her Ph.D. in molecular biology and neuroscience, and was looking for stable work in scientific research or biotechnology. However, when she arrived in Tacoma, Washington, she was disappointed by the opportunities available to her.
“With Puget Sound, in the Pacific Northwest, so outdoorsy…Most of Tacoma is environmental science, which is not my background,” Judy says. “I had a hard time finding anywhere to fit in.”
Judy finally found a position with an engineering company, but she didn’t feel quite at home. One day, her boss sent her out for an external meeting with a professor who had, she was told, “cool ideas.” She was instructed to establish a connection and return with ideas for how her company could collaborate with the “crazy professor.” As it turns out, that “crazy professor” had an idea for an organization to spark a revolution in the life science community around Tacoma.
Today NASA’s InSight lander will touch down on Mars. InSight, which launched on May 5, is NASA’s first Mars landing since the Curiosity rover in 2012. The lander will begin a two-year mission to study Mars’ deep interior, gathering data that will help scientists understand the formation of rocky planets, including Earth.
While every spacecraft that reaches Mars offers more knowledge of the Red Planet, a lot of the excitement is fueled by hopes that someday these missions will bring humans to Mars and enable us to start colonies there. While this goal seems very distant, tremendous progress is being made. Scientists around the globe are making incremental discoveries that will lead to the advances necessary to make colonization of Mars a reality.
The South Pole was exactly as I expected—snowy and barren, apart from the giant research station in front of me. Suddenly, I got a notification in my communication system that there was a strong signal coming from the sky. I looked up and changed the visual display settings of my goggles to find stunning views of the Solar System, all the way past Pluto. My heads-up display told me that I’ve discovered a subatomic particle, called a neutrino, that flies through the fabric of space at nearly the speed of light. I wanted to find the source of this neutrino, so I switched my display to X-ray vision. The signal brightened, and the source was revealed—a massive black hole. I captured as much data as possible so I could report back to the lead scientist on the project. What an exciting afternoon of research!
Okay, I’ve never actually been to the South Pole, but I experienced this event in virtual reality at a conference expo booth for the National Science Foundation. This experience put me in the shoes of an astrophysicist working at the IceCube Neutrino Detection Facility, operated by UW-Madison researchers. As someone who specializes in the life sciences, I had the opportunity to learn more about an area outside my expertise—the fascinating world of particle physics.
Most people think of augmented reality (AR) and virtual reality (VR) in the context of gaming or entertainment. You’ve likely had a casual AR experience if you’ve ever given yourself a flower crown in Snapchat, or hunted for Charmander at your local park with the Pokémon GO app. Yet, as I experienced at a conference several weeks ago, AR and VR can have massive implications for education and training experiences in the sciences. Continue reading “Virtual Reality Is Changing How We Experience Science”
Last month, several of my Promega colleagues and I attended the 2018 iGEM Giant Jamboree in Boston, MA. This annual event is the culmination of the International Genetically Engineered Machines competition, in which 350+ teams of high school, undergraduate and graduate students use synthetic biology to solve a problem they see in the world.
The iGEM Giant Jamboree is the closest I have ever come to a scientific utopia. For four days, several thousand students from 45 countries come together to share their experiences and discuss ways that science can change the world. They present impressive projects with real-world applications including human diagnostics and alternative energy. Collaboration and open science are among the core tenets of iGEM, and it’s not unusual to see three or more countries represented on the Collaborators slide at the end of a presentation. Each project also contains a public engagement component, which many teams fulfill with educational programs or partnerships with underrepresented communities. Continue reading “In a Perfect World, Bacteria Wins”
The 2018 iGEM Giant Jamboree is upon us! This Wednesday, October 24th, thousands of you will flood into Boston, weighed down by posters and presentation materials, but energized by the excitement of a non-stop science-packed conference. Promega will also be attending, with a booth full of helpful giveaways and staff standing by to answer all your questions about science, Promega or future careers. As you make your final plans for the Jamboree, here are a few helpful tips for making the most of this incredible opportunity.
The keynote speaker for this year’s International Symposium on Human Identification (ISHI), Andrew Hessle, describes himself as a catalyst for big projects and ideas (1). In biology, catalysts are enzymes that alter the microenvironment and lower the energy of activation so that a chemical reaction that would proceed anyway happens at a much faster rate—making a reaction actually useful to the biological system in which it occurs.
In practical terms, Andrew Hessel is the person who helps us over our inertia. Instead of waiting for someone else, he sees a problem, gathers an interested group of people with diverse skills and perspectives, creates a microenvironment for these people to interact, and runs with them straight toward the problem. Boom. Reaction started.
Every year, groups of teenagers gather together and brainstorm ways to save the world—with science. The International Genetically Engineered Machine (iGEM) Foundation is a non-profit organization that is dedicated to educating young scientists and enhancing open community and collaboration in the field of synthetic biology. They hold a competition every year with hundreds of teams participating from around the world.
Last year, Promega provided cloning reagents to the University of Chicago iGEM team, and they received a bronze medal for their work. We asked two of the team members, Steve Dvorkin and Julia Byeon, about their experience. Steve is a junior and majors in biology; he is co-president of the team this year. Julia recently graduated and works in public policy. Continue reading “iGEM: Saving the World with Science”