Tick, Tock! The Molecular Basis of Biological Clocks

A long time ago, before the rise of humans, before the first single celled organisms, before the planet even accumulated atmospheric oxygen, Earth was already turning, creating a 24-hour day-night cycle. It’s no surprise, then, that most living things reflect this cycle in their behavior. Certain plants close their leaves at night, others bloom exclusively at certain times of day. Roosters cock-a-doodle-doo every morning, and I’m drowsy by 9:00 pm every night. These behaviors roughly align with the daylight cycles, but internally they are governed by a set of highly conserved molecular circadian rhythms.

Jeffrey Hall, Michael Rosbash and Michael Young were awarded the 2017 Nobel Prize in Physiology/Medicine for their discoveries relating to molecular circadian rhythms. The official statement from the Nobel Committee reads, “…this year’s Nobel laureates isolated a gene that controls the normal daily biological rhythm. They showed that this gene encodes a protein that accumulates in the cell during the night, and is then degraded during the day. [They exposed] the mechanism governing the self-sustaining clockwork inside the cell.” What, then, does this self-sustaining clockwork look like? And how does it affect our daily lives (1)?

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Lessons from My Kindergartener’s First Podcast

I am a podcast junkie. In a given week I will listen to 15-20 podcast episodes, while only watching a couple television shows. Podcasts allow me to partake in my favorite pastime, learning, while offering distraction from mundane and time-consuming activities.

Podcasts help me pass the time during my daily 1.5+ hour round trip commute, while running (including during races) and in waiting rooms or airport terminals. Not surprisingly, many of these include science podcasts.

So, I was ecstatic to hear about a new science podcast for kids, Wow in the World, that I could share with my 5-year-old daughter. I considered it an experiment, assuming that she would listen to one or two episodes and lose interest, not expecting her to stay engaged by 20 minutes of audio alone.

I couldn’t have been more wrong. Within a few seconds, she was singing along with the theme song and after a couple minutes she was fully engaged and asking questions about what was being discussed. In a world where our DVR is filled with a backlog of recorded shows for her to watch on TV, she had trouble understanding that we had to wait until next week for another episode. In the meantime, she enthusiastically listened to the same episode 3 or 4 times, picking up something new each time.

This particular podcast really honed in on topics sure to spark interest in kids, such as the velocity of poop, tooting cows and slug slime. But they also addressed more abstract subject matter like human origins, G-forces and space science, explaining complex new scientific discoveries in an entertaining and memorable way.

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A Nickel’s Worth of Free Advice: Biotech and the Law

This year’s participants in Emerging Techniques in Protein and Genetic Engineering, a two-credit graduate course offered in partnership with the Department of Oncology, UW-Madison, held July 17-21, 2017.

Today’s author extends thanks to Heather Gerard, Intellectual Property Manager, Promega Corporation for contributing her expertise to this post.

Students most often come to the BTC Institute with the primary goal of learning about molecular biology technologies. Our mission is to help them update their experimental tool-box, facilitating more capable studies of DNA, RNA and proteins back in their home laboratories.

But what else do we do? Well, we’re glad you asked. Continue reading

Five Summer Science Projects that are so Fun Your Kids Won’t Realize They are Learning

It is summer here in Wisconsin and the kids are out of school. If you are like me, you are looking for things to keep them busy and (bonus!) maybe teach them something. Below is a list of relatively easy, do-at-home science projects that can be fun for the whole family to try.

Parental supervision is recommended/required for these. And if you don’t want to worry about major clean up (or repainting walls and ceilings) you might want to do these outside whenever possible. I might be speaking from personal experience on this point, so trust me.

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Five Ways to Explain CRISPR Without Delivering a Lecture

Recently a FaceBook friend of mine (who is not a scientist) shared a video from WIRED Science where the concept of CRISPR is explained at 5 Levels of Difficulty— for a 7 year old, a teenager, a college student, a grad student and a CRISPR expert.

First it was pretty amazing to me that my non-scientist friends are interested enough in learning about CRISPR to share this type of information—perhaps showing just how popular and exciting the method has become. People outside the scientific field are hearing a lot about it, and are curious to know more.

This video does a great job of explaining the technique for all its intended audiences. It also is a nice illustration of how to share information in an easily understandable format. Even with the 7 year old and 14 year old, the information is shared in a conversational way, with everyone involved contributing to sharing information about CRISPR.

Really nice. Here’s the WIRED video:


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March for Science—Every Day

Kindergarten teacher and children looking at bird's nest in librEarth Day, April 22, saw one of many of the marches on Washington, D.C. that 2017 has produced: The March for Science.

A march is a shout, a “Hey, over here, you need to hear this” one-time event. It is not a conversation. It really isn’t even action. It’s a start that requires follow up.

But how do you follow up a massive, organized march that happened across the globe? Consider following it up with little things, at every opportunity:

First, say “yes” to opportunities to be an ambassador for science. Continue reading

Calling All Science PUNdits

As the point of contact for our social media efforts at Promega, I spend a lot of time scanning science-related Twitter, Facebook, Instagram media accounts. There are some science channel managers who do a great job of bringing delight to their followers. Those managers use their platforms to educate—I follow them because they constantly amaze me with new things. I find information that is useful, fun and makes me think “wow, that is interesting.” On my favorite accounts, that new learning comes along with a wry sense of humor, and some of my favorite social media channels are ones that not only teach me new things but do it with a little fun on the side—often in the form of bad science puns.

Promega has the privilege of sponsoring the Cool Science Image contest run by the University of Wisconsin-Madison. Just recently @UWMadScience tweeted about the deadline for the contest, tagging @promega in the tweet. Their tweet included a visual science pun which was not lost on their fellow campus account managers:


That pun started a chain reaction among the other UW accounts that follow @UWMadScience: Continue reading

Biotechnology Youth Apprentice Madhu Gowda Wins GRAND PRIZE at the Capital Science and Engineering Fair

Madhu presents her work.

Madhu presents her work.

Imagine the pleasure Barbara Bielec, the BTC Institute’s K-12 Program Director and co-coordinator of the Dane County Youth Apprenticeship Program in Biotechnology (YAP-Biotechnology), felt when reading this recent message from Sharon Tang, one of our apprentice’s mentors:

“I am unbelievably proud to let you know that Madhu won not only first place for the biological science projects, but also the GRAND PRIZE at the Capital Science and Engineering Fair this weekend! She was at the fair from 7:30am until 4:30pm presenting her work done in our lab and did a fantastic, eloquent job speaking about her project. This was such an impressive honor – she won among over 20 competing students in the region, earned a cash award, and will be competing as a finalist at the Intel international science fair in May. I’m sure she’ll tell you, but I am just over the moon and wanted to share the news as well. Attaching a photo I took of her in action.”

A second year student in the program, Madhu is a senior at Middleton High School. Since November, 2015, she has been working in the lab of Dr. Susan Thibeault in the Department of Surgery, Division of Otolaryngology – Head & Neck Surgery at the University of Wisconsin-Madison. Continue reading

Sitting on the Moon

Today’s blog is from BTCI Instructor and guest blogger Jackie Mosher.

Shoot for the moon. Even if you miss, you’ll land among the stars. —Norman Vincent Peale

mosher_a_editThis motivational quote has echoed throughout my life from childhood.  It has inspired me to be fearless in dreaming, to be ambitious and to reach for those goals without fearing failure. So, naturally at the ripe age of 10, my goal was to become a scientist and discover a cure to both AIDS and cancer with a secondary plan of becoming this nation’s first female President. However, as I grew older, I realized my genuine interest and excitement for science and that I enjoyed not only learning about various scientific concepts but also sharing this information with others. Therefore, I completed a Bachelor’s of Science degree with a major in Molecular Biology and minor in Chemistry and decided to continue my studies as a graduate student at UW-Madison in the Cancer Biology graduate program.  My goal was to graduate and aid in disseminating scientific knowledge.

Why teach and not become a scientist? 

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Back to Basics: Organizing Your Writing like It’s a Hamburger

The "hamburger" scheme for organizing a paragraph.

The “hamburger” scheme for organizing a paragraph.

Last night I was helping my daughter, who is in fourth grade, with her homework. We had completed a math worksheet, a geography worksheet and had moved onto writing. For her paragraph assignment, she was supposed to write about a special place. So I began drawing the concept map that we typically use to help her organize her thoughts. She stopped me before I could get started.

“No Mom, wait,” she grabbed the pencil and paper from my hands, “I have a better idea.”

She drew five shapes on the paper.

“We should write the paragraph like it’s a hamburger. The first sentence is the topic—it’s the top of the burger, tells you what is inside—it makes you hungry to read more. Next comes the juicy, meaty part. Three details—three sentences. Then the bottom bun, the summary that supports the whole paragraph. It’s the hardest to write.” She proudly sat down with her drawing and pencil.

“I LOVE that,” I exclaimed. “That’s a great way to organize a paragraph.”

“Yeah,” my husband looked up from his Suduko that he had been working on, “and the cheese goes right here.” He pointed to one of the three boxes my daughter had drawn underneath the bun.

“And the lettuce over here,” my daughter giggled.

“Well, I like mine with lettuce and tomato,” I chanted with no apologies to Jimmy Buffett, “Heinz 57 and French-fried potato..,”

“A big kosher pickle,” my daughter joined in, and the evening’s homework activities degenerated from there. (Sometimes it’s the parents who are easily distracted.)

My daughter’s hamburger graphic was new to me, but the concept wasn’t. It is a solid method for organizing a piece of writing, and it can be applied all kinds of writing—from a paragraph, to an essay, to a speech and even to a scientific article. Continue reading