Wellness and Nutrition

Congenital Cytomegalovirus: The Most Common Congenital Infection That You Have Never Heard Of

Posted on by Kelly Grooms
infant

Down Syndrome. Fetal alcohol syndrome. Spina bifida. Most people have heard of these well know congenital conditions, and know at least in a general sense that they have profound and lasting effects on the children born with them as well as their families. Unfortunately, people are much less aware of a congenital infection that is more common that any of these and affects more infants than all three of the conditions listed above. In fact, this congenital infection causes more cases of congenital disease than all of the 29 conditions currently screened for in most American states combined (1; 2), and yet it is not widely known by the general public. Cytomegalovirus, or CMV, is the most common congenital viral infection in developed countries (3; 4), and the leading cause of congenital sensorineural hearing loss and psychomotor retardation (1).

Continue reading “Congenital Cytomegalovirus: The Most Common Congenital Infection That You Have Never Heard Of”

Finding Space for Passion: Interview with Promega Quality Assurance Scientist, Matt Hanson

Posted on by Michele Arduengo, PhD
QA Senior Scientist Matt Hanson
QA Senior Scientist Matt Hanson

When he was a kid, Matt Hanson would disappear into the basement for an entire day and emerge later with a completed model of the USS Constitution or a completed robot or a new rocket (he still makes model rockets). Design and how things fit together have always fascinated him, so a career in science was a natural fit as well.

Today Matt is a Quality Control Supervisor/QA Senior Scientist at Promega Corporation at the Madison, WI, USA, campus. He has been with Promega for 5 years now.

After completing his undergraduate studies in molecular biology, a masters in zoology where he focused on cell biology, and a PhD in developmental biology and immunology, Matt was fortunate to pursue a successful and rewarding career as an Associate Staff Scientist in the Department of Surgery at the University of Wisconsin-Madison. His work focused on diabetes and transplantation biology.

So why did Matt join the scientific staff at Promega?

Continue reading “Finding Space for Passion: Interview with Promega Quality Assurance Scientist, Matt Hanson”

A Reason for Ribonuclease: From Laboratory Nuisance to Cancer Therapeutic

Posted on by Kari Kenefick

"RNase A". Licensed under CC BY-SA 2.5 via Wikimedia Commons - https://commons.wikimedia.org/wiki/File:RNase_A.png#/media/File:RNase_A.png
“RNase A”. Licensed under CC BY-SA 2.5 via Wikimedia Commons – https://commons.wikimedia.org/wiki/File:RNase_A.png#/media/File:RNase_A.png

RNase, back in the early 1990s, posed a serious threat to laboratories working with RNA isolation. My graduate work involved isolating RNA from the tissues of Lyme disease-infected mice and hamsters. We struggled to DEPC-treat glass and plasticware, or autoclave anything that could be autoclaved, kept tissues cold during RNA harvest and held our breaths (truly, as aerosol could be another source of ribonuclease) until PAGE proved us successful in RNA isolation.

Ribonuclease (RNase) was omnipresent and the arch rival of our work, across several species, due to its RNA destroying abilities.

Now, a July 13, 2015 publication by researchers at the University of Wisconsin-Madison provided both a catch-up for this former lab rat on modern day research with and knowledge of RNase, as well as an exciting look at what may be a real purpose for this RNA-destroying molecule: RNase has moved to clinical trials due to the discovery of it’s cytotoxicity for cancer cells.

Raines’ group in the Department of Chemistry at UWI-Madison published in ACS Central Science their findings on the ligand that RNase 1 uses to attach to human cancer cells, in the article, “Human Cancer Antigen Globo H is a Cell-Surface Ligand for Human Ribonuclease 1”. Continue reading “A Reason for Ribonuclease: From Laboratory Nuisance to Cancer Therapeutic”

Wellness at Work: Pedal to Petal Summer Bike Event and Other Initiatives

Posted on by Roberta Braga

Corporate wellness programs have been discussed in the media over the past few years, and as I read more about them this week, I discovered that the tangible benefits of such programs are vast, ranging from blood pressure and cholesterol management, to stress reduction and mental wellness. I also came across articles claiming wellness initiatives don’t encourage healthy behavior beyond the requirements, or can be an invasion of privacy when employees are required to submit to comprehensive health screenings. Do corporate wellness programs really work? In my experience, they are indispensable. Wellness programs can serve as motivational starting points for employees interested in leading healthier lifestyles and are thus a very positive component of a company’s culture. In my case, the programs offered at Promega greatly facilitated my personal efforts to become more active and mindful.

Bike PicAs many Wisconsinites can attest, staying active in Wisconsin during the winter months can be incredibly challenging. Even walking from your car to the gym might cause your eyes to water and fingers to go numb from the cold. It is no wonder that when given the chance to snuggle up on a warm couch or to go for a run in the brisk weather this winter, I chose the former. Continue reading “Wellness at Work: Pedal to Petal Summer Bike Event and Other Initiatives”

ProMindful

Posted on by Becca McKnight

Mindfulness is all over the news these days, with people touting research-backed benefits like stress reduction, better grades, improved emotional regulation and even boosting you towards your weight loss goals. Here at Promega we have offered yoga classes and meditation sessions for years, and we just finished an 8 week internally developed mindfulness training program.

The approach was to present mindfulness techniques in a “profoundly lighthearted” way. As participants, we were encouraged to be our own test subjects and experiment. In the 30-minute Friday group sessions we learned about a new aspect of mindfulness through teachings, stories and practice and were then encouraged to practice throughout the week. The results were nothing less than life-changing for some participants. Here are a few techniques you can experiment with incorporating into your life.
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Explorations into the Body of Consciousness: Highlights from Dr. Charles Raison’s talk from the International Forum on Consciousness

Posted on by Karin Borgh

Forum attendees have dinner with speakers.
Forum attendees have dinner with speakers.

The following blog highlights the presentation from Dr. Charles Raison at the International Forum on Consciousness, Conscious Evolution: The Awakening, co-hosted by the BTC Institute and Promega Corporation, May 7–8, 2015.

The Forum is designed to bring together people from diverse perspectives and professions to facilitate public dialogue regarding complex and challenging issues.  This year, our intent was to respond to voices of wisdom and action that call for us to shift our consciousness up a notch.

Our goals included building on the lessons of past and present in order to grow further into new systems, new ways of being that may better allow us to foster a long-term, sustainable relationship with the biosphere and the ever-evolving cosmos.

A full house of 325+ attendees, we were guided by eight outstanding presenters, all of whose talks and panel discussions may be viewed via links from our website (http://www.btci.org/consciousness/).   Our first speaker, Dr. Charles Raison, who recently joined the faculty of the University of Wisconsin , effectively set the stage for the Forum, piquing interest for the talks and discussions that followed, as well as the many related conversations that continue to flow.

A few highlights from his talk:

  • Science strives for objectivity but every scientist has a personal motivation regarding the work they’ve come to do.
  • Quoting John Muir, “When we try to pick out anything by itself we find it hitched to everything else in the universe.” Looking at consciousness this way is interesting – not mystical, but actually scientific.

Continue reading “Explorations into the Body of Consciousness: Highlights from Dr. Charles Raison’s talk from the International Forum on Consciousness”

Genetically Modified Mosquitoes Fight Malaria

Posted on by Terri Sundquist
Image courtesy of James Gathany and the CDC
Image courtesy of James Gathany and the CDC

Mosquitos: They are the scourge of summer activities—the annoying buzzing noise as they fly around our ears and the pain, itching and swelling associated with their bites. Worst of all, certain species of mosquitoes can transmit diseases such as West Nile virus, Dengue fever and malaria. Defense mechanisms such as mosquito repellent, covering my head with netting and wearing heavy clothing are often insufficient against the swarm of hungry insects. It’s enough to make me want to stay indoors.

Those people who cannot escape these pests have a higher risk of being bitten and contracting a disease such as malaria, which killed an estimated 627,000 people in 2012, mostly in Africa and southeast Asia (1). A common step in malaria reduction programs in high-risk areas is reducing the number of Anopheles gambiae mosquitoes, which act as the host for malaria-causing parasites. This often involves massive amounts of insecticides, including limited amounts of the much maligned but very effective insecticide dichlorodiphenyltrichloroethane (DDT). Due to these programs, the World Health Organization (WHO) estimates that between 2000 and 2012, malaria mortality rates decreased by 42% worldwide, including a 48% decrease in children under 5 years of age. Clearly these programs are saving lives, but wouldn’t it be nice to achieve the same thing with fewer pesticides?

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Lessons From the ‘Long Goodbye’

Posted on by Ben Schmidt
Lewy Body stained with alpha-synuclein.
Lewy Body stained with alpha-synuclein.

A week ago Sunday, I walked among crowds of mothers, grandmothers, and children of all ages celebrating Mother’s Day at the Botanical Gardens in St. Louis, Missouri.  As I watched happy families, I couldn’t help being jealous.  Though I was there with my grandmother and other close relatives, I missed my mom, especially since I was in my hometown for her funeral the day before.  Had my mom been alive and well, we might have walked those same paths ourselves and enjoyed the new life teeming above the earth.  Instead, my mother lost her battle of more than six years with Lewy Body dementia the week before at the age of 61.

As a biologist, I was well-aware of Alzheimer disease in the abstract, and tau proteins, beta-amyloid, and genetic predisposition.  But until my mom was diagnosed in 2008, I was painfully ignorant of dementias other than Alzheimer disease.  Once we knew what mom was fighting, I learned that Alzheimer disease and Lewy Body are hardly unique.  The number of other dementias that exist is long and includes vascular dementia, mixed dementia, Parkinson’s disease, frontotemporal dementia, Creutzfeldt-Jakob disease, Huntington disease, and many others.[1]

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Biology of Overeating and the Weight-Gain Cycle

Posted on by Anupama Gopalakrishnan

ScaleA person needs to browse through any health related journal, magazine or website to find new and novel ways to reduce weight. While the options range from bariatric surgery to good old “eat-less-exercise-more” concepts, it is intriguing how the more weight a person gains, the harder it is to shed the extra calories. Losing weight is an uphill battle for majority of us. And that got me thinking about how much our biology cooperates while we try to lose weight. I came across these two elegant studies that explain why this is indeed an uphill battle. Continue reading “Biology of Overeating and the Weight-Gain Cycle”

Ghosts

Posted on by Sam Jackson

buddhabrot fractal image
Formless, recursive and abstract, it can be tough to wrestle the ghosts of the conscious mind.

Please believe me when I say this is the hardest thing I’ve done. Typing this sentence might as well be lifting a boulder, and the next could be even heavier. Before this, the hardest thing I’d done was say “good morning” to co-workers, and before that, it was simply getting out of bed.

Just about the only thing I find easy is going to bed, but sleeping is a different story. Every night I lie down, unsure if I’ll fall asleep within seconds and wake what seems like moments later, swatting aimlessly at my alarm clock, or if I’ll remain awake, tired beyond belief but some mysterious finger in the dyke preventing a flood of sleep from washing over me.

I’m one of the approximately 21 million people in the United States who suffer from major depression. Let me tell you, it’s kind of a bummer. Lying awake at night might sound terrible, but it’s the easiest thing in the world compared to writing a sentence, saying “hello”, smiling. I live each day negotiating a watery fog, often unsure what people tell me, confused about what comes next, and desperate for the energy to participate in the world.

This isn’t an essay asking for sympathy; receiving pity from others would only make me feel worse. Besides, as a function of suffering from depression, I’m convinced nobody is reading this, that nobody is going to read this. This essay is for me. Only by engaging and grappling with this disease in words and in actions can I ever hope to pin it to the ground.

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