In this blog, Dr. Jolanta Vidugiriene, Senior Research Scientist at Promega Corporation, discusses tools for studying metabolism in NAFLD/NASH research.

What is nonalcoholic fatty liver disease (NAFLD)?

NAFLD is not a simple disease, it is an umbrella term for a range of liver conditions. The main defining characteristic of NAFLD is fat accumulation in the liver, called steatosis. In about 20% of people, steatosis is accompanied by inflammation, which is a more severe form of NAFLD called NASH (nonalcoholic steatohepatitis). NASH can progress to more advanced conditions like liver cirrhosis and liver failure. Most of the time, NAFLD is associated with underlying conditions—it is closely related to metabolic dysfunction, obesity, and type 2 diabetes. To better reflect the disease pathology, there has been a lot of discussion in the field recently to rename NAFLD to MAFLD, for metabolic associated fatty liver disease. Even though NAFLD has been studied for many years, the causes and progression of the disease are still not well understood. There are no FDA-approved diagnostic tools or treatments for it yet.

Many of the traits characteristic to human pregnancy are unique. In contrast to other mammals, human pregnancy and labor last longer, and humans are more prone to complications, including infertility, preeclampsia and preterm birth. Research recently published in eLife Sciences by Vincent Lynch, PhD, and colleagues explores the history of gene expression in the human uterus, how it differs from other mammals and how changes in expression may be implicated in our susceptibility to disease.

This study is part of the emerging field of evolutionary medicine, where researchers apply modern evolutionary theory to help us understand the mechanisms behind human health and disease. By studying the history of gene expression, researchers and physicians can illuminate the pathways through which evolution has guided the development of modern tissues and organ systems, and how these systems may differ in one species versus the next.

Today’s guest blog was written in collaboration with Melissa Martin, a former global marketing intern with Promega. She is a senior at the University of Wisconsin-Madison where she is double majoring in zoology and life sciences communication, with a certificate in environmental studies.

Have you ever found yourself wondering what the newest advancements were on genetically engineering plants or using artificial intelligence in biotechnology but didn’t know where to start looking? You most likely know the basic science behind the headlines, but a general web search may lead to dramatized articles that focus more on getting attention than being accurate. Or you might find a scholarly article that will offer in-depth, peer-reviewed information but may require more time to read than you are willing to give.

Today’s guest blog is written by Sophie Mancha, a former global marketing intern with Promega. She is in her 4th year as a PhD candidate in the Biomedical Engineering Department at the University of Wisconsin-Madison, studying pancreatic cancer.

Whether you are applying for a scholarship or trying to land a position in a research lab, there are plenty of decisions to make. Arguably, the most critical consideration is what documents to include to showcase that you are the right person for the job. Specifically, should you be preparing a curriculum vitae (CV) or a resume? What exactly is the difference?

This blog is part four of a four-part series on grant writing inspired by resources published by the National Institutes of Health (NIH) and others. 

After a long and arduous journey, you have finally arrived at the last stage of your quest to create the world’s most inspiring grant proposal: writing it all down.  

One of the most challenging parts of putting together a grant proposal is simply writing it. You must write to build the reviewers’ confidence in you and demonstrate your contributions to your field, effectively illustrating your qualities as a researcher and your capacity to achieve your goals.