What Counts as Evidence

This is the third post of three in a series leading up to the 16th annual International Forum on Consciousness, taking place in Madison this May. Hosted by the BTC Institute, Promega and Usona Institute, the forum gathers scientists, philosophers, and practitioners from dozens of different fields to investigate the nature of the mind. This year’s theme, “Unspoken Intelligence,” explores forms of perception and knowing that fall outside conventional cognition.

In 1845, mathematician Urbain Le Verrier calculated where an unseen planet had to be based on irregularities in Uranus’s orbit, wrote a letter to an observatory telling them where to point their telescope, and Neptune was there. He found a planet without ever looking up.

This is what third-person inquiry looks like at its best: observe from the outside, measure what anyone with the right instruments can measure, build a model precise enough to predict what no one has seen yet. Then look. The history of science is full of such moments, equations pointing to phenomena that hadn’t been detected, particles that hadn’t been observed, forces that hadn’t been measured. The method works because it is ruthlessly disciplined about what counts as evidence. The observer is removed, the conditions controlled, and the measurement trusted.

That discipline is not a limitation. It is the engine of over four centuries of extraordinary results. It gave us germ theory, the structure of DNA, and the sequenced human genome. Every time something seemed to resist physical explanation, the method eventually found the mechanism and the method held. The winning streak was long enough that the assumption underneath it stopped looking like an assumption. Outside-in, third-person, measurable evidence stopped looking like one way of knowing. It started looking like the definition of knowing itself.

The assumption felt safe because it had earned its confidence. Digestion, heredity, mental illness, each had seemed to resist physical explanation until it didn’t. The pattern was consistent enough that the method felt inevitable rather than chosen.

Then science turned toward consciousness, and the winning streak entered dangerous territory.


Here is the problem, what philosopher David Chalmers named the “hard problem” of consciousness in 1995.

To understand what Chalmers meant, it helps to start with his own illustration. When you see red, something measurable happens. Light hits the retina. Signals travel along the optic nerve. Specific regions of the visual cortex activate in patterns that neuroscientists can map with increasing precision. All of that is, in principle, fully describable by the third-person, outside-in approach. Given enough time and instruments, you can trace the whole sequence.

What you cannot describe from the outside is what red looks like. The redness of red, that specific quality of experience that exists only in the moment of seeing it, is not in the neural map. No better scanner will find it there, because the felt quality of the experience isn’t a physical thing hiding in the data. It exists only from the inside. The outside measurement, however precise, cannot reach it.

Chalmers used “hard” deliberately, in contrast to what he called the “easy problems” of consciousness: how the brain integrates information, focuses attention, produces behavior. Those are genuinely difficult, but the outside-in approach knows how to go after them. The hard problem is different in kind. It’s the question that remains even after you’ve solved all of the “easy” ones: why does any of it feel like anything at all?

Think of it this way: everything the brain does could, in principle, happen without any felt experience attached. Processing, responding, behaving, all of it could run like a machine in the dark, with no one home. The question Chalmers is asking is why it doesn’t. Philosophers ask it this way: why is there something it’s like to be you, right now, reading this?

No amount of outside-in evidence, however precise, touches that question, not because the science is insufficient but because the method was specifically designed to exclude first-person data. That exclusion was the whole point. It’s what made the outside-in approach so powerful everywhere else.

With consciousness, the method’s central design decision runs into a question it wasn’t built to answer: how do you study first-person experience when your method was built to exclude first-person data?

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The Filter You Didn’t Choose

This is the second post in a series leading up to the 16th annual International Forum on Consciousness, taking place in Madison this May, hosted by the BTC Institute, Promega and Usona Institute. The Forum gathers scientists, philosophers, and practitioners from dozens of different fields to investigate the nature of the mind. This year’s theme, “Unspoken Intelligence,” explores forms of perception and knowing that fall outside conventional cognition.

When she thought about a dog, she saw a dog, more specifically, every dog she had ever encountered, cycling through her mind like a card catalog with pictures attached. She assumed everyone did this. When she discovered they didn’t, that most people access something more like an abstract concept hovering somewhere between language and image, she was genuinely surprised. Temple Grandin had always known her mind didn’t work the way people expected. What she didn’t know, until she was an adult, was the specific shape of the difference.

Most of us know this story, or one like it. We understand that some minds filter experience differently, but the science on this doesn’t stop where the conversation usually does.


For most of its history, the field that mapped minds like Grandin’s looked at those that didn’t fit the available systems and concluded the minds were broken. (It didn’t ask whether the systems were.) More recently, the conversation has been reframing those minds not as deficient but as different.

For many people, that reframing has been transformative, changing how educators teach, how clinicians diagnose, and how workplaces are designed. We are now more familiar with alternative cognitive profiles such as autistic pattern recognition (like that experienced by Grandin), ADHD-associated divergent thinking, and the hyper-focused depth of what researchers call monotropic attention. These are not broken versions of normal cognition. They are different architectures, each with genuine capabilities that other minds aren’t built to produce.

The terms most commonly used to describe these differences, neurotypical and neurdivergent, are useful shorthand but they describe a binary the underlying biology doesn’t support. Cognitive traits distribute across a population the way most biological traits do. “Neurotypical” minds are simply closer to the statistical center. What we call “neurodivergent” can be better understood as the part of that population that differs visibly enough from the statistical center to make the variation impossible to ignore.


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The Body Already Knows

This is the first post in a series leading up to the 16th annual International Forum on Consciousness, taking place in Madison this May, hosted by the BTC Institute, Promega and Usona Institute. The Forum gathers scientists, philosophers, and practitioners from dozens of different fields to investigate the nature of the mind. This year’s theme, “Unspoken Intelligence,” explores forms of perception and knowing that fall outside conventional cognition.

There’s a quote that travels well in some intellectual circles:

You don’t have a soul. You are a soul. You have a body.

There’s something genuinely relieving about that idea. It locates the real you somewhere above the fray, untouched by the body’s demands and indignities, the consciousness that thinks and persists while the body handles the inconvenient work of being hungry and tired and sick. The thinking part is what counts.

Plato thought something similar. So did Augustine. As did Descartes. Kant, too. The idea that the thinking self is separate from and superior to the body is Western civilization’s default setting.

It sounds like wisdom. It is also, I’ve come to think, exactly the wrong way to understand what we are.

Here’s a different text, one most millennials can recite from memory. In the opening verse of “Lose Yourself,” Eminem rattles off a visceral catalog of physical symptoms: sweaty palms, weak knees, heavy arms, vomiting. The body staging a complete revolt while the mind tries to execute a plan, until the moment on stage when the mouth opens and nothing comes out. The mind wanted to perform, but the body said no.

Nobody who has memorized those lyrics thinks of them as a description of embodied cognition. They file it under music, or nostalgia, or just a song they played too loud in a car they didn’t own. But the nervous system doesn’t care what you call it, because the body doesn’t catalogue in words.

This is the thing the soul-body quote gets wrong: the body isn’t a vehicle the self rides around in. It’s already thinking, already keeping score, already running a process the mind is only partially aware of. The question is what to do about that.

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2023 Promega iGEM Grant Winners: Tackling Global Problems with Synthetic Biology Solutions

On June 15, 2023, we announced the winners of the 2023 Promega iGEM grant. Sixty-five teams submitted applications prior to the deadline with projects ranging from creating a biosensor to detect water pollution to solving limitations for CAR-T therapy in solid tumors. The teams are asking tough questions and providing thoughtful answers as they work to tackle global problems with synthetic biology solutions. Unfortunately, we could only award nine grants. Below are summaries of the problems this year’s Promega grant winners are addressing.

UCSC iGEM

An immature night heron against the green surface of Pinto Lake. 2023 Promega iGEM Grant Winner, UCSC iGEM seeks to mitigate these harmful aglal blooms.
A night heron hunts on Pinto Lake, California.

The UCSC iGEM team from the University of California–Santa Cruz is seeking a solution to mitigate the harmful algal blooms caused by Microcystis aeruginosa in Pinto Lake, which is located in the center of a disadvantaged community and is a water source for crop irrigation. By engineering an organism to produce microcystin degrading enzymes found in certain Sphingopyxis bacteria, the goal is to reduce microcystin toxin levels in the water. The project involves isolating the genes of interest, testing their efficacy in E. coli, evaluating enzyme production and product degradation, and ultimately transforming all three genes into a single organism. The approach of in-situ enzyme production offers a potential solution without introducing modified organisms into the environment, as the enzymes naturally degrade over time.

IISc-Bengaluru

Endometriosis is a condition that affects roughly 190 million (10%) women of reproductive age worldwide. Currently, there is no treatment for endometriosis except surgery and hormonal therapy, and both approaches have limitations. The IISc-Bengaluru team at the Indian Institute of Science, Bengaluru, India, received 2023 Promega iGEM grant support to investigate the inflammatory nature of endometriosis by targeting IL-8 (interleukin-8) a cytokine. Research by other groups has snow that targeting IL-8 can reduce endometriotic tissue. This team will be attempting to create an mRNA vaccine to introduce mRNA for antibody against IL-8 into affected tissue. The team is devising a new delivery mechanism using aptides to maximize the delivery of the vaccine to the affected tissues.

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From Biotechnology Youth Apprenticeship to Full-Time Promega Scientist

Headshot photos of Emily Torio, Lucas Slivicke and Kirsten Wingate, three Promega scientists who participated in the Youth Apprenticeship Program.

The Biotechnology Youth Apprenticeship Program hosted by the BTC Institute gives high school students an opportunity to gain hands-on experience in a research lab. Students can work as paid apprentices for either one or two years while also attending weekly training sessions at the BioPharmaceutical Technology Center. Through this program, students can graduate high school with robust knowledge of lab safety and fundamental techniques, as well as a strong understanding of the soft skills required to succeed in science, from reading peer-reviewed literature to delivering a research presentation.

Many of these students will grow up to pursue careers in science, from academic research labs to the biotechnology industry. Some of them have returned to Fitchburg to work at Promega, the primary corporate sponsor of BTC Institute. As these scientists progress in their careers, the skills they developed in the Youth Apprenticeship Program continue to support their work every day.

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The Bell Burnell Observatory: 140 Years of Inspiring Scientific Curiosity

The Bell Burnell Observatory, located at Promega Madison

On a hill at the top of the Promega Madison campus, an old observatory overlooks the city of Fitchburg, Wisconsin. Inside, cutting-edge telescopes are ready to give students and astronomers breathtaking views of the cosmos.

Over the past 140 years, this observatory has served as the first launchpad for storied careers in astronomy. Following a relocation, it gave a passionate community a home for their curiosity. Today, it supports modern research while also welcoming stargazers of all ages. It is now one of the oldest operational observatories in the United States. This is the Bell Burnell Observatory.

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The BTC Institute: Serving Youth Skills and Science for Summer

World Youth Skills Day provides a unique opportunity to emphasize the importance of equipping young people with experiences, skills, and opportunities in the workforce. This celebratory day falls on July 15th and was officially declared by the United Nations General Assembly in 2014.

At Promega, we are constantly adhering to invest in the future generations of science—and the BioPharmaceutical Technology Center Institute (BTC Institute) serves this mission best. The BTC Institute is a non-profit organization that provides educational, scientific, and cultural opportunities for people of all ages. Each summer, the organization hosts a wide range of experiences including camps, programs, and field trips to support individuals interested in science. In the spirit of World Youth Skills Day, let’s take a look at some experiences that are offered for young learners in summer 2022.

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Promega Highlights Innovative Work with Brazil Young Researcher Award


In late May 2022, Promega invited the nine finalists for the Promega Brazil Young Researcher Award to present their work at a Student Research Symposium on the Promega Madison campus.

Scientists from around Brazil recently traveled to Madison, WI, USA as part of the Brazil Young Researcher Award

The Brazil Young Researcher Award program was created to acknowledge exceptional work by Brazilian students utilizing Promega products in their research. These student researchers were recognized for their achievements and were given the opportunity to present their innovative research to Promega scientists as part of a week-long immersive experience on the Promega campus.

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Empowered Women Empower Women: Closing the Confidence Gap in STEM

Welcome back to the third and final part of our Women in Science series, where we’ve been exploring the key factors that perpetuate the gender gap in STEM. In Part 1 of this series, Breaking the Bias: Addressing the STEM Gender Gap, we dug into the key factors of gender stereotypes and male-dominated culture. Part 2, This is What a Scientist Looks Like: The Importance of Female Role Models in STEM, was all about the issue of fewer visible female role models in STEM. Last but certainly not least, this installment will focus on tackling the issue of the confidence gap, including the factors that play into it and the myriad ways we see it unfolds.

Part of my exploration of this topic included having conversations with a handful of my incredible female colleagues at Promega about the challenges women in STEM face. These colleagues were (in no particular order): Becky Godat, Instrumentation Scientist; Jacqui Mendez-Johnson, Quality Assurance Scientist; Johanna Lee, Content Lead, Marketing Services; Jen Romanin, Sr. Director, IVD Operations and Global Support Services; Kris Pearson, Director, Manufacturing & Custom Operations; Leta Steffen, Supervisor, Scientific Applications; Monica Yue, Technical Services Scientist; and Poonam Gunjal, Manager, Regional Sales.

What is the Confidence Gap?

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This is What a Scientist Looks Like: The Importance of Female Role Models in STEM

Welcome back to Part 2 of our March Women in Science series! In Part 1 of this series, Breaking the Bias: Addressing the STEM Gender Gap, we took a closer look at gender stereotypes and male-dominated culture and their roles as key factors in perpetuating the gender gap in STEM. In this installment, we will be continuing the conversation about the STEM gender gap and focusing on the key issue of fewer female role models in STEM.  

Part of my exploration of this topic included having conversations with a handful of my female colleagues at Promega about the about the challenges women in STEM face. These colleagues were (in no particular order): Monica Yue, Technical Services Scientist; Poonam Gunjal, Manager, Regional Sales; Becky Godat, Instrumentation Scientist; Leta Steffen, Supervisor, Scientific Applications; Kris Pearson, Director, Manufacturing & Custom Operations; Jacqui Mendez-Johnson, Quality Assurance Scientist; Johanna Lee, Content Lead, Marketing Services; and Jen Romanin, Sr. Director, IVD Operations and Global Support Services.

What Does A Scientist Look Like?

If someone asked you to draw a scientist, what would that person look like? Over the past 5 decades, this question has been asked of over 20,000 students across all grades from kindergarten through 12th, and evaluated in nearly 80 studies. A meta-analysis of these decades of studies revealed some interesting findings.

Between 1966 and 1977, of the 5,000 drawings collected from students during the original 11-year study, only 28 of those 5,000 drawings (less than 1% of the drawings) depicted a female scientist, with all 28 of them being drawn by girls.

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