Updated June 30, 2025

Targeting a single protein and making it disappear from the cell is quite the magic trick, and there are various molecular tools available for this task. You can use RNA interference, which prevents a protein from being made, inhibitors that bind the protein, rendering it unavailable for use or even gene editing tools like CRISPR that can remove the encoding gene from the genome. Also, you can target an existing protein for destruction, using the cell’s own garbage disposal system to degrade the protein, and you can even expand the concept of targeted degradation to other kinds of macromolecules, such as RNA.

Continue reading “Targeted Degradation: It’s Not Just for PROTACs (or Proteins) Any More”