While you and I are getting some shut eye each night, things are happening in our brains. Good things. Therapeutic things.
Think of it as brainwashing of a sort. There is a multiplicity of brain activities going on during sleep, and a November 1 paper in Science shows for the first time when and where in the brain these activities occur, and how they are connected.
Here’s a bit of backstory.
To assess both the progression and pathogenesis of Alzheimer’s disease (AD), as well as the efficacy of AD drugs in clinical trials, there has been interest in the concentrations of amyloid-beta (Aβ) and tau protein in cerebral spinal fluid (CSF).
It is hard to undermine the role of cleanliness in disease prevention, both internally and externally. Within our body, the lymphatic system plays an important role in clearing the intercellular passages of large and potentially harmful toxic molecules and recirculate back into the blood stream. This enables the transport of these molecules to liver for inactivation and subsequent removal from the body. Therefore, lymphatic system prevents build-up of soluble proteins in the interstitial space. Typically, more metabolically active a cell is, more intricate is the lymphatic vasculature around it. This observation was in contrast to our scientific knowledge a few years ago, when we believed that due to the presence of the blood-brain barrier, there was no lymphatic system active in the brain. The brain, as we know, is highly active metabolically and the removal of harmful solutes and proteins from the neuronal vicinity is of utmost urgency. For a long time it was believed that cerebrospinal fluid (CSF), while coursing through the brain also removed cellular metabolite by products, apart from carrying nutrients to brain tissue, through a process known as diffusion. This is a rather slow process and it did not very well explain how large molecules such as proteins were removed from the interstitial place.
Recently, using two-photon imaging technique in live mice, scientists at Rochester discovered (1) that there is another vasculature functioning in the brain which circulates CSF to every corner of the brain much more efficiently, through bulk flow or convection. Continue reading “A Clean Brain Is a Healthy Brain”