Joins Nominees for Best New Drug Discovery & Development Product 2017
SelectScience® nominates NanoBRET™ Target Engagement Kinases Assay as a Best New Drug Discovery & Development product for 2017.
We were honored recently to have NanoBRET™ Target Engagement Intracellular Kinase Assays nominated by SelectScience® as one of the Best New Drug Discovery & Development Products of 2017. This is a Scientists’ Choice Award®, an opportunity for scientists like you worldwide to vote for your favorite new drug discovery/development product.
We are super excited about both the nomination and the NanoBRET™ Target Engagement Intracellular Kinase Assay. Here is a little information about the assay.
Traditional techniques for studying protein:protein interactions (e.g., affinity capture or mass spectrometry) are limited in that they present a static picture of what is a dynamic process. To gain a more accurate and complete picture of interactions, they need to be studied n the context of the cellular environment within which they occur. In the webinar: Monitoring Protein:Protein Interactions in Living Cells Using NanoBRET™ Technology, Dr. Danette Daniels presented an improved Bioluminescence Resonance Energy Transfer (BRET) Technology that was developed to specifically study dynamic interactions in living cells. The NanoBRET™ Technology combines the small, extremely bright NanoLuc® Luciferase as the donor with a fluorescently labeled HaloTag® protein fusion tag as the acceptor to form a BRET assay. This assay offers an increased signal and decreased spectral overlap compared to other BRET technologies. Among other things, these features provide a larger signal range and the brightness of the NanoLuc® Luciferase enables protein:protein interaction analysis even with the donor protein expressed at low levels. Continue reading