![Cell-free protein expression helped researchers take a closer look at DNA double-strand breaks.](https://www.promegaconnections.com/wp-content/uploads/2021/02/61282668-FebBlog-CellFreeProteinExpression-TW-1024x512-1.jpg)
A new article in Nature Scientific Reports answers open questions about TOPBP1, a protein involved in repairing DNA double-strand breaks (DSBs). The study used cell-free protein expression and a unique DSB system to identify domains that were important for activation of a protein kinase.
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