In the late-80’s through the 90’s, food and health agencies focused
on a mysterious fatal brain disease that infected thousands of cattle. Bovine
spongiform encephalitis—or “mad cow disease”—is caused by an infectious protein
called a prion. Despite fears that tainted meat would cause the disease to
spread to humans, mad cow disease never really made an impact on human health.
However, forms of the prion disease such as Creutzfeldt-Jakob disease do affect
In addition to Creutzfeldt-Jakob disease, many neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s and amyotrophic lateral sclerosis (ALS or Lou Gehrig’s disease) are now thought to be a result of prion-like activity. There is no cure for these diseases, however, new experimental treatment strategies might help slow the progression of neural degeneration.
Imagine driving in your car and suddenly not recognizing where you, you don’t remember where you were going and have no idea how to find your way home. What if you looked across the breakfast table at your spouse and no longer recognizing them? Or maybe you have to brace yourself every time you visit your parent, waiting for the day when they won’t know who you are. This is reality for the estimated 50 million (worldwide) Alzheimer’s suffers and their families.
For a world with an aging population, Alzheimer’s is a growing problem. Recent estimates suggest that 11% of people over the age of 65 have Alzheimer’s disease. For people 85 and older, that number increases to 32% (1).
Alzheimer’s disease is a devastating degenerative brain disease. It is the most common cause of dementia, and is characterized by a decline in cognitive skills such as memory, language skills, communication and problem solving abilities. These symptoms make it difficult for people with Alzheimer’s to perform everyday activities. It also is difficult to diagnose, even more difficult to treat, and, as of now, impossible to cure. Continue reading “Restoring Memory in Alzheimer’s Mice with Microbubbles and Ultrasound”
Forgetting. Forgetting your address; your spouse; your children; your friends; your life. It is something that none of us want to think about, but it hangs over some of us like a specter. Can’t remember if you fed the cat? Where you put your car keys? Did you forget to pack your lunch or return a phone call? Maybe you are trying to do too many things at once, or maybe you are tired. There are lots of perfectly normal reasons why we all forget things from time to time, but every time I forget something there is a nagging voice in my head saying, “Maybe it is something else.” Continue reading “Remembering Not to Forget”