Vaccine research and development is a major area of focus for life scientists across the globe. Clinical trials have shown that vaccines that target tumors show promise for cancer treatment. Additionally, the emergence of new zoonotic diseases has revealed a need to develop vaccines quickly as the world becomes more global and human populations interact […]
While PROTACs might not be the topic of conversation at high society cocktail parties, or merit cover stories in glamor magazines, they’re certainly shaking up the drug discovery industry. PROTAC® degraders, together with related compounds like molecular glues and LYTACs, are the basic tools for a targeted protein degradation strategy. Research in this field is […]
With use and time things wear out. Tires get worn on a car, and you have the old tires removed, recycled, and replaced with new ones. Sometimes a part or piece of something isn’t made properly. For instance, if you are assembling a piece of furniture and you find a screw with no threads, you […]
G protein-coupled receptors (GPCRs) comprise a large group of cell surface receptors, characterized by the unique structural property of crossing the cell membrane seven times. They respond to a diverse group of signaling molecules, such as peptides, neurotransmitters, cytokines, hormones and other small molecules (1). Upon activation, GPCRs interact with GTP-binding (G) proteins and arrestins […]
The University of Dundee in Scotland and Promega Corporation have developed a new approach to targeted protein degradation: a revolutionary “three-headed hydra” with a unique three-pronged structure that packs a powerful punch.
Updated June 30, 2025 Targeting a single protein and making it disappear from the cell is quite the magic trick, and there are various molecular tools available for this task. You can use RNA interference, which prevents a protein from being made, inhibitors that bind the protein, rendering it unavailable for use or even gene […]
PROTACs or Proteolysis-Targeting Chimeras are an emerging tool in protein degradation studies, potentially suited to any need involving the removal of a specific protein. These small-molecule chimeras are exciting due to: 1) their target specificity; and 2) their ability to enable target destruction versus target inhibition. Here we discuss a paper that presents a roadmap […]
Traditional protein study methods often disrupt the cellular context, impairing functional analysis. CRISPR/Cas9-mediated knock-in allows precise endogenous tagging, enhancing observation of proteins under native conditions. The HiBiT and NanoLuc® technologies enable sensitive, real-time analysis, crucial for drug discovery, offering efficient, scalable solutions for modern molecular biology challenges.
Compared to methods for characterizing compound binding affinity, techniques for assessing kinetic parameters of compound binding can be more laborious (1). Nevertheless, several methodologies have been developed to measure compound residence time, including methods that allow for higher throughput.
Over 90 researchers convened at the 4th TPD & Induced Proximity Symposium to discuss advancements in targeted protein degradation (TPD) and induced proximity. Key topics included chemoproteomics’ role in drug discovery and the integration of AI with mass spectrometry. The meeting underscored the growing community’s commitment to translating proteomic insights into therapeutic innovations.
