NanoBRET™ Target Engagement Intracellular Kinase Assay Nominated for Scientists’ Choice Award®

Joins Nominees for Best New Drug Discovery & Development Product 2017

SelectScience® nominates NanoBRET™ Target Engagement Kinases Assay as a Best New Drug Discovery & Development product for 2017.

We were honored recently to have NanoBRET™ Target Engagement Intracellular Kinase Assays nominated by SelectScience® as one of the Best New Drug Discovery & Development Products of 2017. This is a Scientists’ Choice Award®, an opportunity for scientists like you worldwide to vote for your favorite new drug discovery/development product.

We are super excited about both the nomination and the NanoBRET™ Target Engagement Intracellular Kinase Assay. Here is a little information about the assay.

Diagram of how NanoBRET TE works.

Diagram of how NanoBRET™ TE Kinase Assay works.

The NanoBRET™ Target Engagement Intracellular Kinase Assay is a first-of-its-kind assay that enables researchers to quantitatively measure test compound binding at full-length kinase targets in live cells. The NanoBRET™ Target Engagement Assay measures the apparent affinity of test compounds by competitive displacement of the NanoBRET™ Tracer, reversibly bound to a NanoLuc® luciferase-kinase fusion in cells, as shown in this diagram.

See a Recent Publication

This recent publication in Cell Chemical Biology provides a more in-depth view on NanoBRET™ Target Engagement (TE) Intracellular Kinase Assays: “Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement”.

Vote Here/Now

To encourage you to vote, SelectScience® is offering this incentive: All scientists who vote are entered into a drawing for a chance to win a $500/£400/450€ Amazon voucher.

Are you ready? Here is the list of nominees and your opportunity to vote. Voting closes on January 29, 2018. Don’t miss this chance to participate in the Scientists’ Choice Awards!

More NanoBRET™ Target Engagement Resources

We are hosting a webinar on January 23 that is now open for registration:

Webinar: NanoBRET: A Quantitative Technique to Measure Kinase Target Engagement in Live Cells

The following links provide more detailed information on NanoBRET™ products and resources:

NanoBRET™ Target Engagement Intracellular Kinase Assays

NanoBRET™ Target Engagement HDAC Assays 

NanoBRET™ Target Engagement BET BRD Assays

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Kari Kenefick

Kari has been a science writer/editor for Promega since 1996. Prior to that she enjoyed working in veterinary microbiology/immunology, and has an M.S. in Bacteriology, U of WI-Madison. Favorite topics include infectious disease, inflammation, aging, exercise, nutrition and personality traits. When not writing, she enjoys training her dogs in agility and obedience. About the practice of writing, as we say for cell-based assays, "add-mix-measure".

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